Details

Autor(en) / Beteiligte

• Jabaudon, Matthieu
• Audard, Jules
• Pereira, Bruno
• Jaber, Samir
• Lefrant, Jean-Yves
• Blondonnet, Raiko
• Godet, Thomas
• Futier, Emmanuel
• Lambert, Céline
• Bazin, Jean-Etienne
• Bastarache, Julie A.
• Constantin, Jean-Michel
• Ware, Lorraine B.
• Souweine, Bertrand
• Eisenmann, Nathanael
• Quenot, Jean-Pierre
• Seguin, Philippe
• Asehnoune, Karim
• Lasocki, Sigismond
• Ferrandiere, Martine
• Sossou, Achile
• Langeron, Olivier
• Leone, Marc
• Dupont, Herve
• Veber, Benoit
• Ichai, Carole
• Rimmelé, Thomas
• Legay, François
• Grelon, Fabien
• Dahyot-Fizelier, Claire
• Cayot, Sophie
• Guerin, Renaud
• Verlhac, Camille
• Chabanne, Russell
• Cosserant, Bernard
• Lautrette, Alexandre
• Muller, Laurent
• Massanet, Pablo
• Boutin, Caroline
• Barbar, Saber
• Roger, Claire
• Belafia, Fouad
• Cisse, Moussa
• Monnin, Marion
• Conseil, Matthieu
• Carr, Julie
• De Jong, Audrey
• Chanques, Gérald
• Dargent, Auguste
• Crozon, Thomas
• Clauzel, Julien
• Le Core, Marinne
• Andreu, Pascal
• Lebouvrier, Thomas
• Launey, Yoann
• Roquilly, Antoine
• Cinotti, Raphael
• Tellier, Anne-Charlotte
• Barbaz, Mathilde
• Cohen, Benjamin
• Lemarche, Edouard
• Bertrand, Pierre-Marie
• Arbelot, Charlotte
• Zieleskiewicz, Laurent
• Hammad, Emmanuelle
• Duclos, Garry
• Calypso, Mathieu
• Orban, Jean-Christophe
• Quintard, Hervé
• Assefi, Mona
• Morel, Jerome
• Molliex, Serge
• Petitas, Frank
• Nanadougmar, Hadanou

Titel

Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS

Ist Teil von

• Chest, 2020-12, Vol.158 (6), p.2394-2403

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The Radiographic Assessment of Lung Edema (RALE) score is associated with the severity of ARDS, and treatments targeted at reducing pulmonary edema such as conservative fluid management cause a reduction in RALE score over time. Are early changes in RALE score over time associated with survival in patients with ARDS? Data from patients enrolled in three centers in the Lung Imaging for Ventilation sEtting in ARDS (LIVE) trial with available chest radiographs at baseline (day 0) and days 2 or 3 were used. The RALE was scored by two independent reviewers. The primary end point was death by day 90, considering RALE score both at baseline and as a time-varying covariate in a marginal Cox survival model. RALE was scored from 135, 64, and 88 radiographs on days 0, 2, and 3, respectively. Both baseline RALE (hazard ratio [HR] for each one-point increment, 1.04; 95% CI, 1.01-1.08; P = .006) and the change in RALE over time (HR for each one-point decrease per unit of time, 0.99; 95% CI, 0.99-0.99; P = .03) were associated with death by day 90, even after adjustment for age, sex, BMI, Simplified Acute Physiology Score II, vasopressor use, and total volume of fluids received since study entry. The change in RALE during the first days after ARDS onset is independently associated with survival and may be useful as a surrogate end point in future clinical trials of new therapeutics in ARDS.