The New England journal of medicine, 2021-03, Vol.384 (9), p.795-807
- Kalil, Andre C
- Patterson, Thomas F
- Mehta, Aneesh K
- Tomashek, Kay M
- Wolfe, Cameron R
- Ghazaryan, Varduhi
- Marconi, Vincent C
- Ruiz-Palacios, Guillermo M
- Hsieh, Lanny
- Kline, Susan
- Tapson, Victor
- Iovine, Nicole M
- Jain, Mamta K
- Sweeney, Daniel A
- El Sahly, Hana M
- Branche, Angela R
- Regalado Pineda, Justino
- Lye, David C
- Sandkovsky, Uriel
- Luetkemeyer, Anne F
- Cohen, Stuart H
- Finberg, Robert W
- Jackson, Patrick E.H
- Taiwo, Babafemi
- Paules, Catharine I
- Arguinchona, Henry
- Erdmann, Nathaniel
- Ahuja, Neera
- Frank, Maria
- Oh, Myoung-don
- Kim, Eu-Suk
- Tan, Seow Y
- Mularski, Richard A
- Nielsen, Henrik
- Ponce, Philip O
- Taylor, Barbara S
- Larson, LuAnn
- Rouphael, Nadine G
- Saklawi, Youssef
- Cantos, Valeria D
- Ko, Emily R
- Engemann, John J
- Amin, Alpesh N
- Watanabe, Miki
- Billings, Joanne
- Elie, Marie-Carmelle
- Davey, Richard T
- Burgess, Timothy H
- Ferreira, Jennifer
- Green, Michelle
- Makowski, Mat
- Cardoso, Anabela
- de Bono, Stephanie
- Bonnett, Tyler
- Proschan, Michael
- Deye, Gregory A
- Dempsey, Walla
- Nayak, Seema U
- Dodd, Lori E
- Beigel, John H
2021
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- Autor(en) / Beteiligte
- Kalil, Andre C
- Patterson, Thomas F
- Mehta, Aneesh K
- Tomashek, Kay M
- Wolfe, Cameron R
- Ghazaryan, Varduhi
- Marconi, Vincent C
- Ruiz-Palacios, Guillermo M
- Hsieh, Lanny
- Kline, Susan
- Tapson, Victor
- Iovine, Nicole M
- Jain, Mamta K
- Sweeney, Daniel A
- El Sahly, Hana M
- Branche, Angela R
- Regalado Pineda, Justino
- Lye, David C
- Sandkovsky, Uriel
- Luetkemeyer, Anne F
- Cohen, Stuart H
- Finberg, Robert W
- Jackson, Patrick E.H
- Taiwo, Babafemi
- Paules, Catharine I
- Arguinchona, Henry
- Erdmann, Nathaniel
- Ahuja, Neera
- Frank, Maria
- Oh, Myoung-don
- Kim, Eu-Suk
- Tan, Seow Y
- Mularski, Richard A
- Nielsen, Henrik
- Ponce, Philip O
- Taylor, Barbara S
- Larson, LuAnn
- Rouphael, Nadine G
- Saklawi, Youssef
- Cantos, Valeria D
- Ko, Emily R
- Engemann, John J
- Amin, Alpesh N
- Watanabe, Miki
- Billings, Joanne
- Elie, Marie-Carmelle
- Davey, Richard T
- Burgess, Timothy H
- Ferreira, Jennifer
- Green, Michelle
- Makowski, Mat
- Cardoso, Anabela
- de Bono, Stephanie
- Bonnett, Tyler
- Proschan, Michael
- Deye, Gregory A
- Dempsey, Walla
- Nayak, Seema U
- Dodd, Lori E
- Beigel, John H
- Titel
- Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
- Ist Teil von
- The New England journal of medicine, 2021-03, Vol.384 (9), p.795-807
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In a trial involving 1033 patients hospitalized with Covid-19, the addition of baricitinib to remdesivir was associated with shorter recovery time, particularly among patients receiving high-flow oxygen, and with a 30% higher odds of improvement at day 15 than remdesivir alone. Adverse events were less frequent with the combination therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa2031994Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7745180
- Format
- –
- Schlagworte
- Adenosine Monophosphate - adverse effects, Adenosine Monophosphate - analogs & derivatives, Adenosine Monophosphate - therapeutic use, Adult, Adverse events, Aged, Alanine - adverse effects, Alanine - analogs & derivatives, Alanine - therapeutic use, Allergies, Antiviral Agents - adverse effects, Antiviral Agents - therapeutic use, Antiviral drugs, Azetidines - adverse effects, Azetidines - therapeutic use, Clinical trials, Coronaviruses, COVID-19, COVID-19 - drug therapy, COVID-19 - mortality, COVID-19 - therapy, Cytokines, Design, Disease, Double-Blind Method, Drug Therapy, Combination, Enzyme inhibitors, Female, Hospital Mortality, Hospitalization, Humans, Infectious diseases, Janus kinase, Janus Kinase Inhibitors - adverse effects, Janus Kinase Inhibitors - therapeutic use, Kinases, Male, Middle Aged, Mortality, Original, Oxygen, Oxygen Inhalation Therapy, Patients, Placebos, Purines - adverse effects, Purines - therapeutic use, Pyrazoles - adverse effects, Pyrazoles - therapeutic use, Respiration, Artificial, Severe acute respiratory syndrome coronavirus 2, Statistical analysis, Sulfonamides - adverse effects, Sulfonamides - therapeutic use, Treatment Outcome