Details

Autor(en) / Beteiligte

• Liao, Baolin
• Liu, Zhipeng
• Tang, Libo
• Li, Linghua
• Gan, Qingxin
• Shi, Haiyan
• Jiao, Qian
• Guan, Yujuan
• Xie, Min
• He, Xi
• Zhao, Han
• Chen, Weilie
• Liu, Yanxia
• Li, Liya
• Wang, Yaping
• Cao, Yi
• Shi, Yaling
• Li, Yongyin
• Lei, Chunliang

Titel

Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19

Ist Teil von

• International journal of medical sciences, 2021, Vol.18 (1), p.29-41

Ort / Verlag

Australia: Ivyspring International Publisher Pty Ltd

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• : Previous studies of coronavirus disease 2019 (COVID-19) were mainly focused on cross-sectional analysis. In this study, we sought to evaluate the dynamic changes of immunological and radiographic features, and the association with the outcome of pulmonary lesions in COVID-19 patients. : Peripheral blood samples and radiographic data were collected longitudinally for up to 8 weeks from 158 laboratory-confirmed COVID-19 patients. The chest computed tomography (CT) scans were scored based on a semi-quantification assessment according to the extent of pulmonary abnormalities; the temporal change of the immunological and radiographic features was analyzed. Compared with mild and moderate patients, severe patients had significantly decreased counts of lymphocytes, CD4 T cells, CD8 T cells, and CD19 B cells but dramatically elevated counts of neutrophils and levels of interleukin (IL)-6. Sequential monitoring showed a sustained increase in lymphocytes counts and significantly decreased levels of IL-6 in severe patients during the disease course. Notably, patients with persistent pulmonary lesions (CT score ≥ 5 in week 8) showed high levels of IL-6 during the follow-up period, compared with those with recovery lesions (CT score < 5 in week 8). More importantly, the peak expression of IL-6 prior to the aggravated lung injury was mainly found in patients with persistent lesions, and multivariate analysis showed that IL-6 level upon admission was an independent factor associated with the persistent pulmonary injury. Prolonged elevation of IL-6 is associated with persistent pulmonary lesions in COVID-19 patients. Sequential monitoring and timely intervention of IL-6 may favor the clinical management of COVID-19.