Details

Autor(en) / Beteiligte

• Garcés, Maria Fernanda
• Buell-Acosta, Julieth Daniela
• Rodríguez-Navarro, Haiver Antonio
• Pulido-Sánchez, Estefania
• Rincon-Ramírez, Juan José
• Moreno-Ordóñez, Diana Carolina
• Franco-Vega, Roberto
• Roncancio-Muñoz, Jhoan Sebastian
• Burgos-Cardenas, Alvaro Javier
• Lacunza, Ezequiel
• Castaño, Justo P
• Diéguez, Carlos
• Nogueiras, Rubén
• Sanchez, Elizabeth
• Caminos, Jorge Eduardo

Titel

Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

Ist Teil von

• Scientific reports, 2020-12, Vol.10 (1), p.21118-21118, Article 21118

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m ) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m ) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride-glucose index. Moreover, ANGPTL3-AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.