The EMBO journal, 2020-12, Vol.39 (23), p.e106927-n/a
2020
Details
- Autor(en) / Beteiligte
- Titel
- Tumor start‐up: mitochondrial fusion makes it happen
- Ist Teil von
- The EMBO journal, 2020-12, Vol.39 (23), p.e106927-n/a
- Ort / Verlag
- England: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Whether changes in cellular metabolism precede tumor formation and trigger malignant properties or simply serve as a bioenergetic adaptation of cancer during disease progression remains debated. Bonnay et al (2020) now show that a metabolic reprogramming toward increased oxidative phosphorylation is required for irreversible cell immortalization and subsequent tumor formation. Recent work reports aberrant mitochondrial fusion and increased oxidative phosphorylation as potent metabolic drivers of brain tumors in Drosophila.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0261-4189eISSN: 1460-2075DOI: 10.15252/embj.2020106927Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7705446
- Format
- –
- Schlagworte
- Cell immortalization, Energy Metabolism, Humans, Immortalization, Metabolism, Mitochondria, Mitochondria - genetics, Mitochondria - metabolism, Mitochondrial Dynamics, Neoplasms - genetics, Neoplasms - metabolism, Neural Stem Cells, Oxidative Phosphorylation, Oxidative Stress, Phosphorylation, Tumors, Views