Details

Autor(en) / Beteiligte

• Bacher, Petra
• Rosati, Elisa
• Esser, Daniela
• Martini, Gabriela Rios
• Saggau, Carina
• Schiminsky, Esther
• Dargvainiene, Justina
• Schröder, Ina
• Wieters, Imke
• Khodamoradi, Yascha
• Eberhardt, Fabian
• Vehreschild, Maria J.G.T.
• Neb, Holger
• Sonntagbauer, Michael
• Conrad, Claudio
• Tran, Florian
• Rosenstiel, Philip
• Markewitz, Robert
• Wandinger, Klaus-Peter
• Augustin, Max
• Rybniker, Jan
• Kochanek, Matthias
• Leypoldt, Frank
• Cornely, Oliver A.
• Koehler, Philipp
• Franke, Andre
• Scheffold, Alexander

Titel

Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19

Ist Teil von

• Immunity (Cambridge, Mass.), 2020-12, Vol.53 (6), p.1258-1271.e5

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• CD4+ T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and these are suggested to arise in response to common cold coronavirus (CCCoV) infection. Here, we utilized SARS-CoV-2-reactive CD4+ T cell enrichment to examine the antigen avidity and clonality of these cells, as well as the relative contribution of CCCoV cross-reactivity. SARS-CoV-2-reactive CD4+ memory T cells were present in virtually all unexposed individuals examined, displaying low functional avidity and multiple, highly variable cross-reactivities that were not restricted to CCCoVs. SARS-CoV-2-reactive CD4+ T cells from COVID-19 patients lacked cross-reactivity to CCCoVs, irrespective of strong memory T cell responses against CCCoV in all donors analyzed. In severe but not mild COVID-19, SARS-CoV-2-specific T cells displayed low functional avidity and clonality, despite increased frequencies. Our findings identify low-avidity CD4+ T cell responses as a hallmark of severe COVID-19 and argue against a protective role for CCCoV-reactive T cells in SARS-CoV-2 infection. [Display omitted] •Low avidity and broad cross-reactivities of pre-existing SARS-CoV-2 memory T cells•Strong CCCoV-specific memory CD4+ T cell responses in all analyzed individuals•SARS-CoV-2-specific CD4+ T cells in COVID-19 patients lack cross-reactivity to CCCoVs•Low avidity and clonality of SARS-CoV-2-specific T cell responses in severe COVID-19 Bacher et al. identify excessive but low-avidity T cell responses to SARS-CoV-2 as a hallmark of severe but not mild COVID-19. Pre-existing memory to SARS-CoV-2 in unexposed donors also displayed low avidity and harbored multiple, highly variable cross-reactivities that were not restricted to common cold coronaviruses.