Details

Autor(en) / Beteiligte

• Choi, Pui-Wah
• Bahrampour, Abbas
• Ng, Shu-Kay
• Liu, Sze Kei
• Qiu, Wei
• Xie, Fang
• Kuo, Winston Patrick
• Kwong, Joseph
• Hales, Karen H
• Hales, Dale B
• Wong, Kwong-Kwok
• Norwitz, Errol R
• Chow, Chun Kin
• Berkowitz, Ross S
• Ng, Shu-Wing

Titel

Characterization of miR-200 family members as blood biomarkers for human and laying hen ovarian cancer

Ist Teil von

• Scientific reports, 2020-11, Vol.10 (1), p.20071, Article 20071

Ort / Verlag

England: Nature Publishing Group UK

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• MicroRNA-200 (miR-200) family is highly expressed in ovarian cancer. We evaluated the levels of family members relative to the internal control miR-103a in ovarian cancer and control blood specimens collected from American and Hong Kong Chinese institutions, as well as from a laying hen spontaneous ovarian cancer model. The levels of miR-200a, miR-200b and miR-200c were significantly elevated in all human cancer versus all control blood samples. Further analyses showed significantly higher miR-200 levels in Chinese control (except miR-429) and cancer (except miR-200a and miR141) samples than their respective American counterparts. Subtype-specific analysis showed that miR-200b had an overall elevated level in serous cancer compared with controls, whereas miR-429 was significantly elevated in clear cell and endometrioid cancer versus controls. MiR-429 was also significantly elevated in cancer versus control in laying hen plasma samples, consistent with the fact that endometrioid tumor is the prevalent type in this species. A neural network model consisting of miR-200a/200b/429/141 showed an area under the curve (AUC) value of 0.904 for American ovarian cancer prediction, whereas a model consisting of miR-200b/200c/429/141 showed an AUC value of 0.901 for Chinese women. Hence, miR-200 is informative as blood biomarkers for both human and laying hen ovarian cancer.