Details

Autor(en) / Beteiligte

• Nicolazzo, Chiara
• Loreni, Flavia
• Caponnetto, Salvatore
• Magri, Valentina
• Vestri, Anna Rita
• Zamarchi, Rita
• Gradilone, Angela
• Facchinetti, Antonella
• Rossi, Elisabetta
• Cortesi, Enrico
• Gazzaniga, Paola

Titel

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer

Ist Teil von

• Oncotarget, 2020-11, Vol.11 (45), p.4115-4122

Ort / Verlag

Impact Journals LLC

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• CD44v6, the CD44 isoform mostly involved in cancer cell migration and invasion, has been identified as a functional biomarker and therapeutic target in colon cancer stem cells. We here provide evidence that baseline CD44v6-positive CTC predict treatment failure in patients with metastatic colorectal cancer undergoing first-line chemotherapy. We suggest that CD44v6-positive CTC can be used to early detect intrinsic drug resistance in this cancer type.