Details

Autor(en) / Beteiligte

• Kim, Chun K
• Pak, Toni R

Titel

miRNA degradation in the mammalian brain

Ist Teil von

• American Journal of Physiology: Cell Physiology, 2020-10, Vol.319 (4), p.C624-C629

Ort / Verlag

United States: American Physiological Society

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• MicroRNAs (miRNAs) are short, noncoding RNAs that are evolutionarily conserved across many different species. miRNA regulation of gene expression, specifically in the context of the mammalian brain, has been well characterized; however, the regulation of miRNA degradation is still a focus of ongoing research. This review focuses on recent findings concerning the cellular mechanisms that govern miRNA degradation, with an emphasis on target-mediated miRNA degradation and how this phenomenon is uniquely poised to maintain homeostasis in neuronal systems.