Details

Autor(en) / Beteiligte

• Chikina, Aleksandra S.
• Nadalin, Francesca
• Maurin, Mathieu
• San-Roman, Mabel
• Thomas-Bonafos, Thibault
• Li, Xin V.
• Lameiras, Sonia
• Baulande, Sylvain
• Henri, Sandrine
• Malissen, Bernard
• Lacerda Mariano, Livia
• Barbazan, Jorge
• Blander, J. Magarian
• Iliev, Iliyan D.
• Matic Vignjevic, Danijela
• Lennon-Duménil, Ana-Maria

Titel

Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption

Ist Teil von

• Cell, 2020-10, Vol.183 (2), p.411-428.e16

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The colon is primarily responsible for absorbing fluids. It contains a large number of microorganisms including fungi, which are enriched in its distal segment. The colonic mucosa must therefore tightly regulate fluid influx to control absorption of fungal metabolites, which can be toxic to epithelial cells and lead to barrier dysfunction. How this is achieved remains unknown. Here, we describe a mechanism by which the innate immune system allows rapid quality check of absorbed fluids to avoid intoxication of colonocytes. This mechanism relies on a population of distal colon macrophages that are equipped with “balloon-like” protrusions (BLPs) inserted in the epithelium, which sample absorbed fluids. In the absence of macrophages or BLPs, epithelial cells keep absorbing fluids containing fungal products, leading to their death and subsequent loss of epithelial barrier integrity. These results reveal an unexpected and essential role of macrophages in the maintenance of colon-microbiota interactions in homeostasis. [Display omitted] [Display omitted] •Epithelium in the distal colon requires macrophages (Мɸs) for survival•Distal colon Мɸs insert “balloon-like” protrusions (BLPs) in the epithelium•BLPs sense fungal toxins within the fluids absorbed through epithelial cells•BLP+ Мɸs prevent the absorption of fungal toxins, protecting the barrier integrity Protrusions on distal colonic macrophages orchestrate fluid sampling, which is critical to protect epithelial cells from absorbing fluids enriched in fungi toxins/metabolites.