Details

Autor(en) / Beteiligte

• Dhar, Mahesh S
• Marwal, Robin
• Vs, Radhakrishnan
• Ponnusamy, Kalaiarasan
• Jolly, Bani
• Bhoyar, Rahul C
• Sardana, Viren
• Naushin, Salwa
• Rophina, Mercy
• Mellan, Thomas A
• Mishra, Swapnil
• Whittaker, Charles
• Fatihi, Saman
• Datta, Meena
• Singh, Priyanka
• Sharma, Uma
• Ujjainiya, Rajat
• Bhatheja, Nitin
• Divakar, Mohit Kumar
• Singh, Manoj K
• Imran, Mohamed
• Senthivel, Vigneshwar
• Maurya, Ranjeet
• Jha, Neha
• Mehta, Priyanka
• A, Vivekanand
• Sharma, Pooja
• Vr, Arvinden
• Chaudhary, Urmila
• Soni, Namita
• Thukral, Lipi
• Flaxman, Seth
• Bhatt, Samir
• Pandey, Rajesh
• Dash, Debasis
• Faruq, Mohammed
• Lall, Hemlata
• Gogia, Hema
• Madan, Preeti
• Kulkarni, Sanket
• Chauhan, Himanshu
• Sengupta, Shantanu
• Kabra, Sandhya
• Gupta, Ravindra K
• Singh, Sujeet K
• Agrawal, Anurag
• Rakshit, Partha
• Nandicoori, Vinay
• Tallapaka, Karthik Bharadwaj
• Sowpati, Divya Tej
• Thangaraj, K
• Bashyam, Murali Dharan
• Dalal, Ashwin
• Sivasubbu, Sridhar
• Scaria, Vinod
• Parida, Ajay
• Raghav, Sunil K
• Prasad, Punit
• Sarin, Apurva
• Mayor, Satyajit
• Ramakrishnan, Uma
• Palakodeti, Dasaradhi
• Seshasayee, Aswin Sai Narain
• Bhat, Manoj
• Shouche, Yogesh
• Pillai, Ajay
• Dikid, Tanzin
• Das, Saumitra
• Maitra, Arindam
• Chinnaswamy, Sreedhar
• Biswas, Nidhan Kumar
• Desai, Anita Sudhir
• Pattabiraman, Chitra
• Manjunatha, M V
• Mani, Reeta S
• Arunachal Udupi, Gautam
• Abraham, Priya
• Atul, Potdar Varsha
• Cherian, Sarah S

Titel

Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

Ist Teil von

• Science (American Association for the Advancement of Science), 2021-11, Vol.374 (6570), p.995-999

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2021

Quelle

Science Online_科学在线

Beschreibungen/Notizen

• Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.