Science (American Association for the Advancement of Science), 2021-07, Vol.373 (6551), p.231-236
2021
Details
- Autor(en) / Beteiligte
- Titel
- An isoform of Dicer protects mammalian stem cells against multiple RNA viruses
- Ist Teil von
- Science (American Association for the Advancement of Science), 2021-07, Vol.373 (6551), p.231-236
- Ort / Verlag
- United States: The American Association for the Advancement of Science
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- In mammals, early resistance to viruses relies on interferons, which protect differentiated cells but not stem cells from viral replication. Many other organisms rely instead on RNA interference (RNAi) mediated by a specialized Dicer protein that cleaves viral double-stranded RNA. Whether RNAi also contributes to mammalian antiviral immunity remains controversial. We identified an isoform of Dicer, named antiviral Dicer (aviD), that protects tissue stem cells from RNA viruses-including Zika virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-by dicing viral double-stranded RNA to orchestrate antiviral RNAi. Our work sheds light on the molecular regulation of antiviral RNAi in mammalian innate immunity, in which different cell-intrinsic antiviral pathways can be tailored to the differentiation status of cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.abg2264Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7611482
- Format
- –
- Schlagworte
- Alternative Splicing, Animals, Brain - enzymology, Brain - virology, Cell differentiation, Cell Line, Coronaviruses, DEAD-box RNA Helicases - chemistry, DEAD-box RNA Helicases - genetics, DEAD-box RNA Helicases - metabolism, Dicer protein, Double-stranded RNA, Gene expression, Homology, Humans, Immunity, Immunity, Innate, Innate immunity, Insects, Interference, Interferon, Isoenzymes - chemistry, Isoenzymes - genetics, Isoenzymes - metabolism, Mammals, Mice, Organoids - enzymology, Organoids - virology, Ribonuclease III - chemistry, Ribonuclease III - genetics, Ribonuclease III - metabolism, RNA Interference, RNA Virus Infections - enzymology, RNA Virus Infections - immunology, RNA Virus Infections - virology, RNA viruses, RNA Viruses - genetics, RNA Viruses - immunology, RNA Viruses - physiology, RNA, Double-Stranded - metabolism, RNA, Small Interfering - metabolism, RNA, Viral - metabolism, RNA-mediated interference, SARS-CoV-2 - genetics, SARS-CoV-2 - immunology, SARS-CoV-2 - physiology, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Stem cells, Stem Cells - enzymology, Stem Cells - virology, Vector-borne diseases, Viral diseases, Virus Replication, Viruses, Zika Virus - genetics, Zika Virus - immunology, Zika Virus - physiology, Zika Virus Infection - enzymology, Zika Virus Infection - immunology, Zika Virus Infection - virology