Details

Autor(en) / Beteiligte

• Ermatov, Timur
• Noskov, Roman E.
• Machnev, Andrey A.
• Gnusov, Ivan
• Аtkin, Vsevolod
• Lazareva, Ekaterina N.
• German, Sergei V.
• Kosolobov, Sergey S.
• Zatsepin, Timofei S.
• Sergeeva, Olga V.
• Skibina, Julia S.
• Ginzburg, Pavel
• Tuchin, Valery V.
• Lagoudakis, Pavlos G.
• Gorin, Dmitry A.

Titel

Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Ist Teil von

• Light, science & applications, 2020-10, Vol.9 (1), p.173-173, Article 173

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Abstract The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy, however, disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain. Here, we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths, with a sensitivity up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU −1 in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.