Details

Autor(en) / Beteiligte

• Lee, Nelson
• Chan, Martin C. W.
• Lui, Grace C. Y.
• Li, Ran
• Wong, Rity Y. K.
• Yung, Irene M. H.
• Cheung, Catherine S. K.
• Chan, Eugenia C. Y.
• Hui, David S. C.
• Chan, Paul K. S.

Titel

High Viral Load and Respiratory Failure in Adults Hospitalized for Respiratory Syncytial Virus Infections

Ist Teil von

• The Journal of infectious diseases, 2015-10, Vol.212 (8), p.1237-1240

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• A prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratorytract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 ± 1.47; day 3-4, 7.28 ± 1.41; day 5-8, 6.66 ± 1.87 log 10 copies/mL). RNA concentration was independently associated with risk of complications and respiratory insufficiency (adjusted odds ratio 1.40 per log 10 copies/mL increase, 95% confidence interval, 1.03-1.90; P= .034). Our data indicate the need and provide a basis for clinical research on antiviral therapy in this population.