Details

Autor(en) / Beteiligte

• Rashidi, Armin
• Herman, Adam
• Gomes, Antonio L. C.
• Peled, Jonathan U.
• Jenq, Robert R.
• Brereton, Daniel G.
• Staley, Christopher
• Blazar, Bruce R.
• Weisdorf, Daniel J.

Titel

An alpha‐defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft‐versus‐host disease

Ist Teil von

• British journal of haematology, 2020-06, Vol.189 (5), p.926-930

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Summary We previously reported a protective association between single nucleotide polymorphisms (SNPs; rs4415345G and rs4610776A alleles) of Paneth cell α‐defensin‐5 against acute graft‐versus‐host disease (aGVHD). Because dysbiosis has been associated with aGVHD, we hypothesized that these SNPs may have a gut microbiota signature. In Lasso regression analysis of 248 healthy individuals, rs4415345G was associated with a higher abundance of Odoribacter splanchnicus, an anaerobic butyrogenic commensal. In multivariable analysis of data from 613 allogeneic haematopoietic cell transplant recipients, peri‐engraftment presence of O. splanchnicus was associated with ~50% lower risk for grade II–IV aGVHD (hazard ratio 0·53, 95% confidence interval 0·28–1·00, P = 0·05). O. splanchnicus may protect rs4415345G individuals against aGVHD.