Details

Autor(en) / Beteiligte

• Liu, Ye-Mao
• Xie, Jing
• Chen, Ming-Ming
• Zhang, Xiao
• Cheng, Xu
• Li, Haomiao
• Zhou, Feng
• Qin, Juan-Juan
• Lei, Fang
• Chen, Ze
• Lin, Lijin
• Yang, Chengzhang
• Mao, Weiming
• Chen, Guohua
• Lu, Haofeng
• Xia, Xigang
• Wang, Daihong
• Liao, Xiaofeng
• Yang, Jun
• Huang, Xiaodong
• Zhang, Bing-Hong
• Yuan, Yufeng
• Cai, Jingjing
• Zhang, Xiao-Jing
• Wang, Yibin
• Zhang, Xin
• She, Zhi-Gang
• Li, Hongliang

Titel

Kidney Function Indicators Predict Adverse Outcomes of COVID-19

Ist Teil von

• Med (New York, N.Y. : Online), 2021-01, Vol.2 (1), p.38-48.e2

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The coronavirus disease 2019 (COVID-19) is a recently emerged respiratory infectious disease with kidney injury as a part of the clinical complications. However, the dynamic change of kidney function and its association with COVID-19 prognosis are largely unknown. In this multicenter retrospective cohort study, we analyzed clinical characteristics, medical history, laboratory tests, and treatment data of 12,413 COVID-19 patients. The patient cohort was stratified according to the severity of the outcome into three groups: non-severe, severe, and death. The prevalence of elevated blood urea nitrogen (BUN), elevated serum creatinine (Scr), and decreased blood uric acid (BUA) at admission was 6.29%, 5.22%, and 11.66%, respectively. The trajectories showed the elevation in BUN and Scr levels, as well as a reduction in BUA level for 28 days after admission in death cases. Increased all-cause mortality risk was associated with elevated baseline levels of BUN and Scr and decreased levels of BUA. The dynamic changes of the three kidney function markers were associated with different severity and poor prognosis of COVID-19 patients. BUN showed a close association with and high potential for predicting adverse outcomes in COVID-19 patients for severity stratification and triage. This study was supported by grants from the National Key R&D Program of China (2016YFF0101504), the National Science Foundation of China (81630011, 81970364, 81970070, 81970011, 81870171, and 81700356), the Major Research Plan of the National Natural Science Foundation of China (91639304), the Hubei Science and Technology Support Project (2019BFC582, 2018BEC473, and 2017BEC001), and the Medical Flight Plan of Wuhan University. [Display omitted] A cohort of 12,413 COVID-19 patients was retrospectively investigatedElevated baseline levels of BUN and Scr correlated with high risk of COVID-19 mortalityDecreased BUA level on admission was associated with high risk of COVID-19 mortality Kidney injury is a common complication of coronavirus disease 2019 (COVID-19); however, the dynamic changes in kidney injury markers and their associations with COVID-19 prognosis remain largely uncertain. Here, using a multicenter retrospective cohort of 12,413 patients with COVID-19 from 17 hospitals in Hubei Province, China, Liu et al. reveal that elevated baseline levels of blood urea nitrogen (BUN) and serum creatinine (Scr), as well as a decreased baseline level of blood uric acid (BUA), are correlated with adverse outcomes of COVID-19. These results confer clinical evidence that kidney function markers may be simple tools for predicting adverse outcomes in COVID-19 patients for severity stratification. Liu et al. show that among 12,413 cases of COVID-19, an elevation in baseline BUN and Scr levels and a decrease in baseline BUA level were associated with adverse outcomes in patients. These findings may assist in the risk stratification and triage of COVID-19 patients according to kidney function indicators.