Details

Autor(en) / Beteiligte

• Hurwitz, Lauren M.
• Yeboah, Edward D.
• Biritwum, Richard B.
• Tettey, Yao
• Adjei, Andrew A.
• Mensah, James E.
• Tay, Evelyn
• Okyne, Vicky
• Truelove, Ann
• Kelly, Scott P.
• Zhou, Cindy Ke
• Butler, Eboneé N.
• Hoover, Robert N.
• Hsing, Ann W.
• Cook, Michael B.

Titel

Overall and abdominal obesity and prostate cancer risk in a West African population: An analysis of the Ghana Prostate Study

Ist Teil von

• International journal of cancer, 2020-11, Vol.147 (10), p.2669-2676

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2020

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Obesity has been associated with an increased risk of advanced prostate cancer. However, most studies have been conducted among North American and European populations. Prostate cancer mortality appears elevated in West Africa, yet risk factors for prostate cancer in this region are unknown. We thus examined the relationship between obesity and prostate cancer using a case‐control study conducted in Accra, Ghana in 2004 to 2012. Cases and controls were drawn from a population‐based sample of 1037 men screened for prostate cancer, yielding 73 cases and 964 controls. An additional 493 incident cases were recruited from the Korle‐Bu Teaching Hospital. Anthropometric measurements were taken at enrollment. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between body mass index (BMI), waist circumference (WC), waist‐hip ratio (WHR) and prostate cancer, adjusting for potential confounders. The mean BMI was 25.1 kg/m2 for cases and 24.3 kg/m2 for controls. After adjustment, men with BMI ≥ 30 kg/m2 had an increased risk of prostate cancer relative to men with BMI < 25 kg/m2 (OR 1.86, 95% CI 1.11‐3.13). Elevated WC (OR 1.76, 95% CI 1.24‐2.51) and WHR (OR 1.46, 95% CI 0.99‐2.16) were also associated with prostate cancer. Associations were not modified by smoking status and were evident for low‐ and high‐grade disease. These findings indicate that overall and abdominal obesity are positively associated with prostate cancer among men in Ghana, implicating obesity as a potentially modifiable risk factor for prostate cancer in this region. What's new? Despite high rates of prostate cancer mortality in West Africa, risk factors for prostate cancer in African populations remain understudied. In this case‐control study, the authors examined relationships between obesity and prostate cancer in cancer patients and healthy controls in Accra, Ghana. Analyses uncovered associations between increased prostate cancer risk and both overall obesity and abdominal obesity. Unlike in Western populations, obesity was associated with both low‐ and high‐grade prostate cancer. The findings identify obesity as an important prostate cancer risk factor in West Africa and shed light on the complexity of the obesity‐prostate cancer relationship in diverse populations.