Journal of cellular and molecular medicine, 2020-09, Vol.24 (18), p.10512-10524
2020
Details
- Autor(en) / Beteiligte
- Titel
- LINC00941 promotes oral squamous cell carcinoma progression via activating CAPRIN2 and canonical WNT/β‐catenin signaling pathway
- Ist Teil von
- Journal of cellular and molecular medicine, 2020-09, Vol.24 (18), p.10512-10524
- Ort / Verlag
- England: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Dysregulation of long non‐coding RNAs (lncRNAs) has been implicated in many cancer developments. Previous studies showed that lncRNA LINC00941 was aberrantly expressed in oral squamous cell carcinoma (OSCC). However, its role in OSCC development remains elusive. In this study, we demonstrated that in OSCC cells, EP300 activates LINC00941 transcription through up‐regulating its promoter H3K27ac modification. Up‐regulated LINC00941 in turn activates CAPRIN2 expression by looping to CAPRIN2 promoter. Functional assays suggest that both LINC00941 and CAPRIN2 play pivotal roles in promoting OSCC cell proliferation and colony formation. In vivo assay further confirmed the role of LINC00941 in promoting OSCC cell tumour formation. Lastly, we showed that the role of LINC00941 and CAPRIN2 in OSCC progression was mediated through activating the canonical WNT/β‐catenin signaling pathway. Thus, LINC00941/CAPRIN2/ WNT/β‐catenin signaling pathway provides new therapeutic targets for OSCC treatment.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1582-1838eISSN: 1582-4934DOI: 10.1111/jcmm.15667Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7521336
- Format
- –
- Schlagworte
- Animals, Cancer therapies, CAPRIN2, Carcinoma, Squamous Cell - genetics, Carcinoma, Squamous Cell - pathology, Catenin, Cell adhesion & migration, Cell cycle, Cell Division, Cell growth, Cell proliferation, Cells, Cultured, Cold, CRISPR-Cas Systems, Deoxyribonucleic acid, Disease Progression, DNA, DNA, Neoplasm - genetics, DNA, Neoplasm - ultrastructure, E1A-Associated p300 Protein - physiology, Gene Expression Regulation, Neoplastic, Genes, Reporter, Genomes, Histone Code, Keratinocytes, Ligands, LINC00941, long non‐coding RNA, Mice, Mice, Inbred BALB C, Mice, Nude, MicroRNAs, Mouth Neoplasms - genetics, Mouth Neoplasms - pathology, Neoplasm Proteins - biosynthesis, Neoplasm Proteins - genetics, Neoplasm Proteins - physiology, Neoplasm Transplantation, Non-coding RNA, Oral cancer, Oral squamous cell carcinoma, Oral Squamous Cell Carcinoma (OSCC), Original, Promoter Regions, Genetic - genetics, Proteins, Recombinant Proteins - metabolism, RNA polymerase, RNA, Guide, CRISPR-Cas Systems, RNA, Long Noncoding - genetics, RNA, Long Noncoding - metabolism, RNA, Neoplasm - biosynthesis, RNA, Neoplasm - genetics, RNA, Neoplasm - physiology, RNA-Binding Proteins - biosynthesis, RNA-Binding Proteins - genetics, RNA-Binding Proteins - physiology, Signal transduction, Squamous cell carcinoma, Transcription, Tumor Stem Cell Assay, Tumors, Up-Regulation, Wnt protein, WNT signaling pathway, Wnt Signaling Pathway - genetics, Wnt Signaling Pathway - physiology