Details

Autor(en) / Beteiligte

• Assimon, Magdalene M.
• Shah, Jatan
• Renaghan, Amanda DeMauro
• Wilson, F. Perry
• Neyra, Javier A.
• Anand, Shuchi
• Edmonston, Daniel
• Walther, Carl P.
• Anumudu, Samaya J.
• Arunthamakun, Justin
• McCullough, Peter A.
• Nguyen, Thuy-Duyen
• Krajewski, Megan L.
• Shankar, Sidharth
• Pannu, Ameeka
• Waikar, Sushrut S.
• Athavale, Ambarish M.
• Green, Adam
• Schorr, Christa A.
• Shehata, Alexandre M.
• Allusson, Valerie
• Mehta, Bijal
• Williams, Aquino
• Altman, Deena R.
• Corona-Villalobos, Celia P.
• Mallappallil, Mary C.
• Nguyen, H. Bryant
• Sirganagari, Dheeraj Reddy
• Guru, Pramod K.
• Zhou, Yan
• Rodriguez, Jesus
• Shah, Jatan A.
• Mocerino, Ryan
• Azzi, Yorg
• Fisher, Molly
• Sedaliu, Kaltrina
• Kumar, Neelja
• Chang, Michael
• Plataki, Maria
• Alvarez-Mulett, Sergio L.
• Krishnan, Jamuna
• Macina, Ashley
• Wu, Benjamin
• Modersitzki, Frank
• Martinez, Carlos
• Hodakowski, Alexander J.
• Velez, Juan Carlos Q.
• Avasare, Rupali S.
• Gupta, Shruti
• Sise, Meghan E.
• Sharma, Shreyak
• Singh, Harkarandeep
• Shaukat, Tanveer
• Kamal, Omer
• Boateng, Jeffery O.
• Lee, Meghan
• Li, Jiahua
• Bickley, Laura
• Byun, John J.
• Sutherland, Anne K.
• Finkel, Diana G.
• Arikapudi, Sowminya
• Cangialosi, Peter
• Liotta, Mark
• Vatson, Jayanth S.
• Levitt, Joseph E.
• Burnham, Ellen L.
• Rashidi, Arash
• Latta, Laura
• Tolwani, Ashita
• Adams, Jason Y.
• Beutler, Rebecca M.
• Monica, Santa
• Macedo, Etienne
• Rhee, Harin
• Liu, Kathleen D.
• Koyner, Jay L.
• Chaaban, Nourhan
• Au, Elizabeth H.
• Sharma, Jill H.
• De La Zerda, David
• Azam, Tariq U.
• Perry, Danny
• Bitar, Abbas
• Donnelly, John P.
• Tugman, Matthew J.
• Miano, Todd A.
• Bansal, Amar D.
• Ernecoff, Natalie C.
• Kapoor, Sanjana
• Chen, Huiwen
• Hedayati, S. Susan
• Shastri, Shani
• Willett, Duwayne L.
• Bhatraju, Pavan K.
• Semler, Matthew W.
• Vijayan, Anitha
• Li, Tingting
• Jose, Aju
• Gupta, Sanjeev

Titel

Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States

Ist Teil von

• American journal of kidney diseases, 2021-02, Vol.77 (2), p.190-203.e1

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Underlying kidney disease is an emerging risk factor for more severe coronavirus disease 2019 (COVID-19) illness. We examined the clinical courses of critically ill COVID-19 patients with and without pre-existing chronic kidney disease (CKD) and investigated the association between the degree of underlying kidney disease and in-hospital outcomes. Retrospective cohort study. 4,264 critically ill patients with COVID-19 (143 patients with pre-existing kidney failure receiving maintenance dialysis; 521 patients with pre-existing non-dialysis-dependent CKD; and 3,600 patients without pre-existing CKD) admitted to intensive care units (ICUs) at 68 hospitals across the United States. Presence (vs absence) of pre-existing kidney disease. In-hospital mortality (primary); respiratory failure, shock, ventricular arrhythmia/cardiac arrest, thromboembolic events, major bleeds, and acute liver injury (secondary). We used standardized differences to compare patient characteristics (values>0.10 indicate a meaningful difference between groups) and multivariable-adjusted Fine and Gray survival models to examine outcome associations. Dialysis patients had a shorter time from symptom onset to ICU admission compared to other groups (median of 4 [IQR, 2-9] days for maintenance dialysis patients; 7 [IQR, 3-10] days for non-dialysis-dependent CKD patients; and 7 [IQR, 4-10] days for patients without pre-existing CKD). More dialysis patients (25%) reported altered mental status than those with non-dialysis-dependent CKD (20%; standardized difference=0.12) and those without pre-existing CKD (12%; standardized difference=0.36). Half of dialysis and non-dialysis-dependent CKD patients died within 28 days of ICU admission versus 35% of patients without pre-existing CKD. Compared to patients without pre-existing CKD, dialysis patients had higher risk for 28-day in-hospital death (adjusted HR, 1.41 [95% CI, 1.09-1.81]), while patients with non-dialysis-dependent CKD had an intermediate risk (adjusted HR, 1.25 [95% CI, 1.08-1.44]). Potential residual confounding. Findings highlight the high mortality of individuals with underlying kidney disease and severe COVID-19, underscoring the importance of identifying safe and effective COVID-19 therapies in this vulnerable population. [Display omitted]