Details

Autor(en) / Beteiligte

• Tiego, Jeggan
• Chamberlain, Samuel R
• Harrison, Ben J
• Dawson, Andrew
• Albertella, Lucy
• Youssef, George J
• Fontenelle, Leonardo F
• Yücel, Murat

Titel

Heritability of overlapping impulsivity and compulsivity dimensional phenotypes

Ist Teil von

• Scientific reports, 2020-09, Vol.10 (1), p.14378, Article 14378

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive-compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A  = 0.33), modest additive genetic or common environmental effects for obsessiveness (A  = 0.25; C  = 0.23), and moderate effects of common environment (C  = 0.36) for the general dimension, This general impulsive-compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors.