Details

Autor(en) / Beteiligte

• Castelnuovo, Augusto Di
• Costanzo, Simona
• Antinori, Andrea
• Berselli, Nausicaa
• Blandi, Lorenzo
• Bruno, Raffaele
• Cauda, Roberto
• Guaraldi, Giovanni
• Menicanti, Lorenzo
• Parruti, Giustino
• Patti, Giuseppe
• Perlini, Stefano
• Santilli, Francesca
• Signorelli, Carlo
• Stefanini, Giulio G.
• Vergori, Alessandra
• Ageno, Walter
• Agodi, Antonella
• Aiello, Luca
• Moghazi, Samir Al
• Astuto, Marinella
• Aucella, Filippo
• Barbieri, Greta
• Bartoloni, Alessandro
• Bonaccio, Marialaura
• Bonfanti, Paolo
• Cacciatore, Francesco
• Caiano, Lucia
• Cannata, Francesco
• Carrozzi, Laura
• Cascio, Antonio
• Ciccullo, Arturo
• Cingolani, Antonella
• Cipollone, Francesco
• Colomba, Claudia
• Crosta, Francesca
• Pra, Chiara Dal
• Danzi, Gian Battista
• D'Ardes, Damiano
• Donati, Katleen de Gaetano
• Giacomo, Paola Del
• Gennaro, Francesco Di
• Di Tano, Giuseppe
• D'Offizi, Giampiero
• Filippini, Tommaso
• Gentile, Ivan
• Gialluisi, Alessandro
• Gini, Giancarlo
• Grandone, Elvira
• Grisafi, Leonardo
• Lamonica, Silvia
• Landi, Francesco
• Leone, Armando
• Maccagni, Gloria
• Maccarella, Sandro
• Madaro, Andrea
• Mapelli, Massimo
• Maragna, Riccardo
• Marra, Lorenzo
• Maresca, Giulio
• Marotta, Claudia
• Mastroianni, Franco
• Mazzitelli, Maria
• Mengozzi, Alessandro
• Menichetti, Francesco
• Meschiari, Marianna
• Minutolo, Filippo
• Montineri, Arturo
• Mussinelli, Roberta
• Mussini, Cristina
• Musso, Maria
• Odone, Anna
• Olivieri, Marco
• Pasi, Emanuela
• Petri, Francesco
• Pinchera, Biagio
• Pivato, Carlo A.
• Poletti, Venerino
• Ravaglia, Claudia
• Rinaldi, Massimo
• Rognoni, Andrea
• Rossato, Marco
• Rossi, Ilaria
• Rossi, Marianna
• Sabena, Anna
• Salinaro, Francesco
• Sanrocco, Carlo
• Scorzolini, Laura
• Sgariglia, Raffaella
• Simeone, Paola Giustina
• Spinicci, Michele
• Trecarichi, Enrico Maria
• Venezia, Amedeo
• Veronesi, Giovanni
• Vettor, Roberto
• Vianello, Andrea
• Vinceti, Marco
• Vocciante, Laura
• De Caterina, Raffaele
• Iacoviello, Licia

Titel

Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study

Ist Teil von

• European journal of internal medicine, 2020-12, Vol.82, p.38-47

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19. We set-up a multicenter Italian collaboration to investigate the relationship between HCQ therapy and COVID-19 in-hospital mortality. In a retrospective observational study, 3,451 unselected patients hospitalized in 33 clinical centers in Italy, from February 19, 2020 to May 23, 2020, with laboratory-confirmed SARS-CoV-2 infection, were analyzed. The primary end-point in a time-to event analysis was in-hospital death, comparing patients who received HCQ with patients who did not. We used multivariable Cox proportional-hazards regression models with inverse probability for treatment weighting by propensity scores, with the addition of subgroup analyses. Out of 3,451 COVID-19 patients, 76.3% received HCQ. Death rates (per 1,000 person-days) for patients receiving or not HCQ were 8.9 and 15.7, respectively. After adjustment for propensity scores, we found 30% lower risk of death in patients receiving HCQ (HR=0.70; 95%CI: 0.59 to 0.84; E-value=1.67). Secondary analyses yielded similar results. The inverse association of HCQ with inpatient mortality was particularly evident in patients having elevated C-reactive protein at entry. HCQ use was associated with a 30% lower risk of death in COVID-19 hospitalized patients. Within the limits of an observational study and awaiting results from randomized controlled trials, these data do not discourage the use of HCQ in inpatients with COVID-19.