IUBMB life, 2020-10, Vol.72 (10), p.2097-2111
2020
Details
- Autor(en) / Beteiligte
- Titel
- Bacterial co‐infections with SARS‐CoV‐2
- Ist Teil von
- IUBMB life, 2020-10, Vol.72 (10), p.2097-2111
- Ort / Verlag
- Hoboken, USA: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The pandemic coronavirus disease 2019 (COVID‐19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2), has affected millions of people worldwide. To date, there are no proven effective therapies for this virus. Efforts made to develop antiviral strategies for the treatment of COVID‐19 are underway. Respiratory viral infections, such as influenza, predispose patients to co‐infections and these lead to increased disease severity and mortality. Numerous types of antibiotics such as azithromycin have been employed for the prevention and treatment of bacterial co‐infection and secondary bacterial infections in patients with a viral respiratory infection (e.g., SARS‐CoV‐2). Although antibiotics do not directly affect SARS‐CoV‐2, viral respiratory infections often result in bacterial pneumonia. It is possible that some patients die from bacterial co‐infection rather than virus itself. To date, a considerable number of bacterial strains have been resistant to various antibiotics such as azithromycin, and the overuse could render those or other antibiotics even less effective. Therefore, bacterial co‐infection and secondary bacterial infection are considered critical risk factors for the severity and mortality rates of COVID‐19. Also, the antibiotic‐resistant as a result of overusing must be considered. In this review, we will summarize the bacterial co‐infection and secondary bacterial infection in some featured respiratory viral infections, especially COVID‐19.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1521-6543eISSN: 1521-6551DOI: 10.1002/iub.2356Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7436231
- Format
- –
- Schlagworte
- Acinetobacter baumannii - drug effects, Acinetobacter baumannii - pathogenicity, Anti-Bacterial Agents - therapeutic use, antibiotic, Antibiotics, Antiviral Agents - therapeutic use, Azithromycin, Bacteria, bacterial co‐infection, Bacterial infections, Bacterial Infections - drug therapy, Bacterial Infections - epidemiology, Bacterial Infections - microbiology, Bacterial Infections - virology, Coinfection, Coronaviruses, COVID-19, COVID-19 - drug therapy, COVID-19 - epidemiology, COVID-19 - microbiology, COVID-19 - virology, Critical Review, Critical Reviews, Haemophilus influenzae - drug effects, Haemophilus influenzae - pathogenicity, Host-Pathogen Interactions - immunology, Humans, Immunity, Innate - drug effects, Infections, Influenza, Klebsiella pneumoniae - drug effects, Klebsiella pneumoniae - pathogenicity, Legionella pneumophila - drug effects, Legionella pneumophila - pathogenicity, Methicillin-Resistant Staphylococcus aureus - drug effects, Methicillin-Resistant Staphylococcus aureus - pathogenicity, Mortality, Pandemics, Pneumonia, Bacterial - drug therapy, Pneumonia, Bacterial - epidemiology, Pneumonia, Bacterial - microbiology, Pneumonia, Bacterial - virology, Pseudomonas aeruginosa - drug effects, Pseudomonas aeruginosa - pathogenicity, Respiratory System - drug effects, Respiratory System - microbiology, Respiratory System - pathology, Respiratory System - virology, Risk factors, SARS-CoV-2 - drug effects, SARS-CoV-2 - pathogenicity, SARS‐CoV‐2, Severe acute respiratory syndrome coronavirus 2, Streptococcus pneumoniae - drug effects, Streptococcus pneumoniae - pathogenicity, Streptococcus pyogenes - drug effects, Streptococcus pyogenes - pathogenicity, viral infection, Viral infections