Details

Autor(en) / Beteiligte

• Schulte-Schrepping, Jonas
• Reusch, Nico
• Paclik, Daniela
• Baßler, Kevin
• Schlickeiser, Stephan
• Krammer, Tobias
• Brumhard, Sophia
• Bonaguro, Lorenzo
• Wendisch, Daniel
• Grasshoff, Martin
• Beckstette, Michael
• Pecht, Tal
• Saglam, Adem
• Dietrich, Oliver
• Mei, Henrik E.
• Schulz, Axel R.
• Conrad, Claudia
• Kunkel, Désirée
• Vafadarnejad, Ehsan
• Xu, Cheng-Jian
• Herbert, Miriam
• Drews, Anna
• Thibeault, Charlotte
• Pfeiffer, Moritz
• Hippenstiel, Stefan
• Hocke, Andreas
• Müller-Redetzky, Holger
• Heim, Katrin-Moira
• Bosquillon de Jarcy, Laure
• Stegemann, Miriam
• Glösenkamp, Christoph R.
• Volk, Hans-Dieter
• Wyler, Emanuel
• Georg, Philipp
• Schneider, Maria
• Dang-Heine, Chantip
• Neuwinger, Nick
• Kappert, Kai
• Corman, Victor
• Raabe, Jan
• Kaiser, Kim Melanie
• Rieke, Gereon
• Meisel, Christian
• Ulas, Thomas
• Becker, Matthias
• Drosten, Christian
• Suttorp, Norbert
• Kurth, Florian
• Schultze, Joachim L.
• Aschenbrenner, Anna C.
• Li, Yang
• Nattermann, Jacob
• Saliba, Antoine-Emmanuel
• Sander, Leif Erik
• Angelov, Angel
• Bals, Robert
• Bartholomäus, Alexander
• Becker, Anke
• Bonifacio, Ezio
• Clavel, Thomas
• Colome-Tatche, Maria
• Diefenbach, Andreas
• Dilthey, Alexander
• Fischer, Nicole
• Förstner, Konrad
• Hain, Torsten
• Hummel, Michael
• Janssen, Stefan
• Kallies, René
• Kehr, Birte
• Keller, Andreas
• Kim-Hellmuth, Sarah
• Klein, Christoph
• Korbel, Jan O.
• Landthaler, Markus
• Ludwig, Kerstin
• Marz, Manja
• McHardy, Alice
• Mertes, Christian
• Nöthen, Markus
• Nürnberg, Peter
• Ohler, Uwe
• Ossowski, Stephan
• Overmann, Jörg
• Peter, Silke
• Pfeffer, Klaus
• Rajewsky, Nikolaus
• Ralser, Markus
• Schulte, Eva-Christina
• Sczyrba, Alexander
• Stoye, Jens
• Theis, Fabian
• Vogel, Jörg
• von Kleist, Max
• Walker, Andreas
• Walter, Jörn
• Wieczorek, Dagmar

Titel

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Ist Teil von

• Cell, 2020-09, Vol.182 (6), p.1419-1440.e23

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19. [Display omitted] •SARS-CoV-2 infection induces profound alterations of the myeloid compartment•Mild COVID-19 is marked by inflammatory HLA-DRhiCD11chi CD14+ monocytes•Dysfunctional HLA-DRloCD163hi and HLA-DRloS100Ahi CD14+ monocytes in severe COVID-19•Emergency myelopoiesis with immature and dysfunctional neutrophils in severe COVID-19 Analysis of patients with mild and severe COVID-19 reveals the presence of dysfunctional neutrophils in the latter that is linked to emergency myelopoiesis.