Oncology letters, 2020-09, Vol.20 (3), p.2587-2594
2020
Details
- Autor(en) / Beteiligte
- Titel
- Long non‑coding RNA GAS5 in human cancer (Review)
- Ist Teil von
- Oncology letters, 2020-09, Vol.20 (3), p.2587-2594
- Ort / Verlag
- Athens: Spandidos Publications
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer, melanoma, esophageal squamous cell carcinoma, lung cancer, ovarian cancer, cervical cancer, gliomas, osteosarcoma, pancreatic cancer, bladder cancer, kidney cancer, papillary thyroid carcinoma, neuroblastoma, endometrial cancer and liver cancer. Notably, GAS5 is overexpressed in liver cancer, potentially functioning as an oncogene. In the present study, the diagnostic and therapeutic roles of GAS5 in different tumors were reviewed, with a summary of the potential clinical application of the lncRNA, which may help identify novel study directions for GAS5. Key words: long non-coding RNA, GAS5, tumor suppressor gene, diagnostic biomarker, therapeutic targe
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1792-1074eISSN: 1792-1082DOI: 10.3892/ol.2020.11809Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7400976
- Format
- –
- Schlagworte
- Androgens, Apoptosis, Bladder cancer, Breast cancer, Cancer, Cancer metastasis, Cancer research, Cancer therapies, Cell cycle, Cell division, Cell growth, Cervical cancer, Colorectal cancer, Digestive system cancer, Disease, Endometrial cancer, Esophageal cancer, Gastric cancer, Genes, Gliomas, Kidney cancer, Lapatinib, Lung cancer, Lymphatic system, Medical diagnosis, Medical prognosis, Melanoma, Metastasis, Mortality, Oncology, Oncology, Experimental, Ovarian cancer, Prostate cancer, Review, RNA, Skin cancer, Squamous cell carcinoma, Stomach cancer, Thyroid diseases, Tumors