Details

Autor(en) / Beteiligte

• Manna, Srimanta
• Dherbassy, Quentin
• Perry, Gregory J. P.
• Procter, David J.

Titel

Enantio‐ and Diastereoselective Synthesis of Homopropargyl Amines by Copper‐Catalyzed Coupling of Imines, 1,3‐Enynes, and Diborons

Ist Teil von

• Angewandte Chemie International Edition, 2020-03, Vol.59 (12), p.4879-4882

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An efficient, enantio‐ and diastereoselective, copper‐catalyzed coupling of imines, 1,3‐enynes, and diborons is reported. The process shows broad substrate scope and delivers complex, chiral homopropargyl amines; useful building blocks on the way to biologically‐relevant compounds. In particular, functionalized homopropargyl amines bearing up to three contiguous stereocenters can be prepared in a single step. The enantio‐ and diastereoselective, copper‐catalyzed three‐component coupling of imines, 1,3‐enynes, and diborons delivers complex, chiral homopropargyl amines; useful building blocks on the way to biologically‐ and medicinally‐relevant compounds. In particular, functionalized homopropargyl amines bearing up to three contiguous stereocenters can be prepared in a single step.