Details

Autor(en) / Beteiligte

• Hernández, Rosendo G.
• De Zeeuw, Chris I.
• Zhang, Ruyan
• Yakusheva, Tatyana A.
• Blazquez, Pablo M.

Titel

Translation information processing is regulated by protein kinase C-dependent mechanism in Purkinje cells in murine posterior vermis

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (29), p.17348-17358

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• The cerebellar posterior vermis generates an estimation of our motion (translation) and orientation (tilt) in space using cues originating from semicircular canals and otolith organs. Theoretical work has laid out the basic computations necessary for this signal transformation, but details on the cellular loci and mechanisms responsible are lacking. Using a multicomponent modeling approach, we show that canal and otolith information are spatially and temporally matched in mouse posterior vermis Purkinje cells and that Purkinje cell responses combine translation and tilt information. Purkinje cell-specific inhibition of protein kinase C decreased and phase-shifted the translation component of Purkinje cell responses, but did not affect the tilt component. Our findings suggest that translation and tilt signals reach Purkinje cells via separate information pathways and that protein kinase C-dependent mechanisms regulate translation information processing in cerebellar cortex output neurons.