Details

Autor(en) / Beteiligte

• Jackson, Lisa A
• Anderson, Evan J
• Rouphael, Nadine G
• Roberts, Paul C
• Makhene, Mamodikoe
• Coler, Rhea N
• McCullough, Michele P
• Chappell, James D
• Denison, Mark R
• Stevens, Laura J
• Pruijssers, Andrea J
• McDermott, Adrian
• Flach, Britta
• Doria-Rose, Nicole A
• Corbett, Kizzmekia S
• Morabito, Kaitlyn M
• O’Dell, Sijy
• Schmidt, Stephen D
• Swanson, Phillip A
• Padilla, Marcelino
• Mascola, John R
• Neuzil, Kathleen M
• Bennett, Hamilton
• Sun, Wellington
• Peters, Etza
• Makowski, Mat
• Albert, Jim
• Cross, Kaitlyn
• Buchanan, Wendy
• Pikaart-Tautges, Rhonda
• Ledgerwood, Julie E
• Graham, Barney S
• Beigel, John H

Titel

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

Ist Teil von

• The New England journal of medicine, 2020-11, Vol.383 (20), p.1920-1931

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Two inoculations with a new SARS-CoV-2 mRNA-based vaccine that encodes a protein in the coronavirus spike elicited high titers of virus-neutralizing antibody in healthy adult volunteers. Virus-specific T-cell responses were also elicited. Interim findings indicated that a dose of 100 μg per injection maximized immune response and minimized the reactogenicity of the vaccine.