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A simple approach to synthesize new highly substituted 4
H
-pyran derivatives is described. Efficient Et
3
N acts as a readily accessible catalyst of this process performed in pure water and with only a 20 mol% of catalyst loading. The extremely simple operational methodology, short reaction times, clean procedure and excellent product yields render this new approach extremely appealing for the synthesis of 4
H
-pyrans, as potentially biological scaffolds. Additionally, DNA interaction analysis reveals that 4
H
-pyran derivatives behave preferably as minor groove binders over major groove or intercalators. Therefore, this is one of the scarce examples where pyrans have resulted to be interesting DNA binders with high binding constants (
K
b
ranges from 1.53 × 10
4
M
−1
to 2.05 × 10
6
M
−1
).