Details

Autor(en) / Beteiligte

• Jordan, Stefan
• Tung, Navpreet
• Casanova-Acebes, Maria
• Chang, Christie
• Cantoni, Claudia
• Zhang, Dachuan
• Wirtz, Theresa H.
• Naik, Shruti
• Rose, Samuel A.
• Brocker, Chad N.
• Gainullina, Anastasiia
• Hornburg, Daniel
• Horng, Sam
• Maier, Barbara B.
• Cravedi, Paolo
• LeRoith, Derek
• Gonzalez, Frank J.
• Meissner, Felix
• Ochando, Jordi
• Rahman, Adeeb
• Chipuk, Jerry E.
• Artyomov, Maxim N.
• Frenette, Paul S.
• Piccio, Laura
• Berres, Marie-Luise
• Gallagher, Emily J.
• Merad, Miriam

Titel

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

Ist Teil von

• Cell, 2019-08, Vol.178 (5), p.1102-1114.e17

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation are poorly understood. Here we show that short-term fasting reduced monocyte metabolic and inflammatory activity and drastically reduced the number of circulating monocytes. Regulation of peripheral monocyte numbers was dependent on dietary glucose and protein levels. Specifically, we found that activation of the low-energy sensor 5′-AMP-activated protein kinase (AMPK) in hepatocytes and suppression of systemic CCL2 production by peroxisome proliferator-activator receptor alpha (PPARα) reduced monocyte mobilization from the bone marrow. Importantly, we show that fasting improves chronic inflammatory diseases without compromising monocyte emergency mobilization during acute infectious inflammation and tissue repair. These results reveal that caloric intake and liver energy sensors dictate the blood and tissue immune tone and link dietary habits to inflammatory disease outcome. [Display omitted] •Fasting reduces the numbers of circulating monocytes in healthy humans and mice•Fasting also reduces monocyte metabolic and inflammatory activity•Hepatic energy-sensing regulates homeostatic monocyte numbers via CCL2 production•Fasting improves inflammatory diseases without compromising antimicrobial immunity Caloric restriction reduces the number of circulating inflammatory monocytes in a CCL2/PPARa-dependent manner, without compromising responses to acute inflammation.