Details

Autor(en) / Beteiligte

• Logtenberg, Meike E.W.
• Scheeren, Ferenc A.
• Schumacher, Ton N.

Titel

The CD47-SIRPα Immune Checkpoint

Ist Teil von

• Immunity (Cambridge, Mass.), 2020-05, Vol.52 (5), p.742-752

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein, expressed on both healthy and cancer cells, plays a pivotal role in this balance by delivering a “don’t eat me signal” upon binding to the Signal-regulatory protein alpha (SIRPα) receptor on myeloid cells. Here, we review the current understanding of the role of the CD47-SIRPα axis in physiological tissue homeostasis and as a promising therapeutic target in, among others, oncology, fibrotic diseases, atherosclerosis, and stem cell therapies. We discuss gaps in understanding and highlight where additional insight will be beneficial to allow optimal exploitation of this myeloid cell checkpoint as a target in human disease. The protein CD47, expressed on both healthy and malignant cells, delivers a “don’t eat me signal” upon binding to the SIRPα receptor on myeloid cells. Schumacher and colleagues discuss the current understanding of the role of the CD47-SIRPα axis in physiological tissue homeostasis and as a promising therapeutic target in, among others, oncology, fibrotic diseases, atherosclerosis, and stem cell therapies.