Details

Autor(en) / Beteiligte

• Pan, Jianbo
• Hu, Yingwei
• Krek, Azra
• Li, Yize
• Chen, Lin S.
• Vasaikar, Suhas
• Wu, Yige
• Chowdhury, Shrabanti
• Wyczalkowski, Matthew A.
• Kong, Andy
• Sethuraman, Sunantha
• Avtonomov, Dmitry M.
• Colaprico, Antonio
• Cao, Song
• Cho, Kyung-Cho
• Kalayci, Selim
• Ma, Shiyong
• Ruggles, Kelly
• Kawaler, Emily
• Wen, Bo
• Chen, Feng
• Edwards, Nathan
• Pierorazio, Phillip M.
• Pavlovich, Christian P.
• Brominski, Gabriel
• Hsieh, James J.
• Lubinski, Jan
• Wiznerowicz, Maciej
• Kinsinger, Christopher R.
• Thiagarajan, Mathangi
• Mesri, Mehdi
• Hiltke, Tara
• Ding, Li
• Zhang, Zhen
• Omenn, Gilbert S.
• Cieslik, Marcin
• Nesvizhskii, Alexey I.
• Zhang, Hui
• Hashimi, Abdul Samad
• Charamut, Alyssa
• Druker, Brian J.
• Tognon, Cristina
• Mani, D.R.
• Rohrer, Daniel C.
• Tansil, Darlene
• Chesla, David
• Heiman, David
• Wheeler, David
• Chan, Doug
• Demir, Emek
• Wilson, George D.
• Liu, Hongwei
• Zhou, Hua
• Day, Jacob
• Suh, James
• Whiteaker, Jeffrey R.
• Eschbacher, Jennifer
• Chen, Jin
• Ketchum, Karen A.
• Rodland, Karin D.
• Krug, Karsten
• Holloway, Kimberly
• Sokoll, Lori J.
• Cornwell, MacIntosh
• Loriaux, Marc
• Anderson, Matthew
• Ellis, Matthew J.
• Dyer, Maureen
• Burke, Meghan C.
• Borucki, Melissa
• Gillette, Michael A.
• Birrer, Michael J.
• Smith, Michael
• Khan, Munziba
• Roche, Nancy
• Edwards, Nathan J.
• Vatanian, Negin
• Tignor, Nicole
• Piehowski, Paul
• McGarvey, Peter B.
• Hariharan, Pushpa
• Gao, Qingsong
• Thangudu, Ratna R.
• Montgomery, Rebecca
• Bremner, Ross
• Liu, Ruiyang
• Hong, Runyu
• Payne, Samuel H.
• Patel, Shalin
• Satpathy, Shankha
• Davies, Sherri R.
• Patil, Snehal
• Carter, Sonya
• Gabriel, Stacey
• Thomas, Stefani N.
• Carr, Steven A.
• Skelly, Tara
• Borate, Uma
• Maruvka, Yosef
• Li, Zhi

Titel

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

Ist Teil von

• Cell, 2019-10, Vol.179 (4), p.964-983.e31

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC and paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration of proteogenomic measurements uniquely identified protein dysregulation of cellular mechanisms impacted by genomic alterations, including oxidative phosphorylation-related metabolism, protein translation processes, and phospho-signaling modules. To assess the degree of immune infiltration in individual tumors, we identified microenvironment cell signatures that delineated four immune-based ccRCC subtypes characterized by distinct cellular pathways. This study reports a large-scale proteogenomic analysis of ccRCC to discern the functional impact of genomic alterations and provides evidence for rational treatment selection stemming from ccRCC pathobiology. [Display omitted] •Integrated proteogenomic characterization in 103 ccRCC cases•Delineation of chromosomal translocation events leading to chromosome 3p loss•Tumor-specific proteomic/phosphoproteomic alterations unrevealed by mRNA analysis•Immune-based subtypes of ccRCC defined by mRNA, proteome, and phosphoproteome Comprehensive proteogenomic characterization in 103 treatment-naive clear cell renal cell carcinoma patient samples highlights tumor-specific alterations at the proteomic level that are unrevealed by transcriptomic profiling and proposes a revised subtyping scheme based on integrated omics analysis.