Details

Autor(en) / Beteiligte

• Miller, Kai J
• Prieto, Thomas
• Williams, Nolan R
• Halpern, Casey H

Titel

Case Studies in Neuroscience: The electrophysiology of a human obsession in nucleus accumbens

Ist Teil von

• Journal of neurophysiology, 2019-06, Vol.121 (6), p.2336-2340

Ort / Verlag

United States: American Physiological Society

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Microelectrode recordings were performed during awake deep brain stimulation surgery for obsessive-compulsive disorder, revealing robust brain oscillations that were plainly visible throughout the ventral striatum. There was an elegant topological correspondence between each oscillation and the underlying brain anatomy, most prominently a ~35Hz gamma-oscillation specific to the nucleus accumbens. Direct provocation of the patient's contamination obsession modulated both firing rate and gamma-oscillation amplitude within the nucleus accumbens.