Details

Autor(en) / Beteiligte

• Manion, Maura
• Dimitrova, Dimana
• Pei, Luxin
• Gea-Banacloche, Juan
• Zelazny, Adrian
• Lisco, Andrea
• Zerbe, Christa
• Freeman, Alexandra F
• Holland, Steven M
• Kanakry, Christopher G
• Kanakry, Jennifer A
• Sereti, Irini

Titel

Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium

Ist Teil von

• Clinical infectious diseases, 2020-02, Vol.70 (4), p.676-679

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2020

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.