Details

Autor(en) / Beteiligte

• Pomés, Anna
• Glesner, Jill
• Calatroni, Agustin
• Visness, Cindy M.
• Wood, Robert A.
• O'Connor, George T.
• Kattan, Meyer
• Bacharier, Leonard B.
• Wheatley, Lisa M.
• Gern, James E.
• Busse, William W.
• Gergen, P.
• Togias, A.
• Smartt, E.
• Thompson, K.

Titel

Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort

Ist Teil von

• Journal of allergy and clinical immunology, 2019-10, Vol.144 (4), p.935-944

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Cockroach is one of the most important sources of indoor allergens and can lead to IgE sensitization and development of rhinitis and asthma. We sought to perform a cockroach allergen component analysis to determine the allergens and antibody levels and patterns of sensitization associated with asthma and rhinitis. Antibody (IgE, IgG, and IgG4) levels to total cockroach and 8 cockroach allergens were determined in 2 groups of cockroach-sensitized 10-year-old children with (n = 19) or without (n = 28) asthma and rhinitis. Allergen-specific antibody levels were measured in streptavidin ImmunoCAPs loaded with each of the recombinant allergens from groups 1, 2, 4, 5, 6, 7, 9, and 11, and total cockroach-specific IgE levels were measured with the i6 ImmunoCAP. IgE antibody levels to cockroach allergens and extract, but not IgG or IgG4 antibody levels, differed between subjects with and without asthma and rhinitis. Specifically, recognition of more cockroach allergens with higher allergen-specific IgE levels was associated with disease. Variable patterns of sensitization with no immunodominant allergens were found in both groups. There was a good correlation between the sum of allergen-specific IgE and total cockroach IgE levels (r = 0.86, P < .001). Component analysis of 8 cockroach allergens revealed significant differences in IgE reactivity associated with the presence of asthma and rhinitis. Allergen-specific IgE titers and sensitization profiles were associated with asthma and rhinitis. [Display omitted]