Details

Autor(en) / Beteiligte

• Wec, Anna Z
• Wrapp, Daniel
• Herbert, Andrew S
• Maurer, Daniel P
• Haslwanter, Denise
• Sakharkar, Mrunal
• Jangra, Rohit K
• Dieterle, M Eugenia
• Lilov, Asparouh
• Huang, Deli
• Tse, Longping V
• Johnson, Nicole V
• Hsieh, Ching-Lin
• Wang, Nianshuang
• Nett, Juergen H
• Champney, Elizabeth
• Burnina, Irina
• Brown, Michael
• Lin, Shu
• Sinclair, Melanie
• Johnson, Carl
• Pudi, Sarat
• Bortz, 3rd, Robert
• Wirchnianski, Ariel S
• Laudermilch, Ethan
• Florez, Catalina
• Fels, J Maximilian
• O'Brien, Cecilia M
• Graham, Barney S
• Nemazee, David
• Burton, Dennis R
• Baric, Ralph S
• Voss, James E
• Chandran, Kartik
• Dye, John M
• McLellan, Jason S
• Walker, Laura M

Titel

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Ist Teil von

• Science (American Association for the Advancement of Science), 2020-08, Vol.369 (6504), p.731-736

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing antibody responses, we mined the memory B cell repertoire of a convalescent severe acute respiratory syndrome (SARS) donor and identified 200 SARS coronavirus 2 (SARS-CoV-2) binding antibodies that target multiple conserved sites on the spike (S) protein. A large proportion of the non-neutralizing antibodies display high levels of somatic hypermutation and cross-react with circulating HCoVs, suggesting recall of preexisting memory B cells elicited by prior HCoV infections. Several antibodies potently cross-neutralize SARS-CoV, SARS-CoV-2, and the bat SARS-like virus WIV1 by blocking receptor attachment and inducing S1 shedding. These antibodies represent promising candidates for therapeutic intervention and reveal a target for the rational design of pan-sarbecovirus vaccines.