Details

Autor(en) / Beteiligte

• Davy, Philip M C
• Allsopp, Richard C
• Donlon, Timothy A
• Morris, Brian J
• Willcox, Donald Craig
• Willcox, Bradley J

Titel

FOXO3 and Exceptional Longevity: Insights From Hydra to Humans

Ist Teil von

• Current topics in developmental biology, 2018, Vol.127, p.193-212

Ort / Verlag

United States

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Aging is a complex, multifactorial process with significant plasticity. While several biological pathways appear to influence aging, few genes have been identified that are both evolutionarily conserved and have a strong impact on aging and age-related phenotypes. The FoxO3 gene (FOXO3), and its homologs in model organisms, appears especially important, forming a key gene in the insulin/insulin-like growth factor-signaling pathway, and influencing life span across diverse species. We highlight some of the key findings that are associated with FoxO3 protein, its gene and homologs in relation to lifespan in different species, and the insights these findings might provide about the molecular, cellular, and physiological processes that modulate aging and longevity in humans.