Neurotherapeutics, 2020-04, Vol.17 (2), p.581-592
2020
Details
- Autor(en) / Beteiligte
- Titel
- Genetic Variation and Response to Neurocritical Illness: a Powerful Approach to Identify Novel Pathophysiological Mechanisms and Therapeutic Targets
- Ist Teil von
- Neurotherapeutics, 2020-04, Vol.17 (2), p.581-592
- Ort / Verlag
- Cham: Springer International Publishing
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- EZB-FREE-00999 freely available EZB journals
- Beschreibungen/Notizen
- Disease-specific therapeutic options for critically ill neurological patients are limited. The identification of new preventive, therapeutic, and rehabilitation strategies is of the utmost importance in the field of neurocritical care research. Population genetics offers powerful tools to identify and prioritize biological pathways to be targeted by novel interventions. New treatments with supportive genetic evidence have twice the chances of obtaining final FDA approval compared to those without this support. Large collaborations, public access to data, reproducible science, and innovative analytical methods have exponentially increased the pace of discoveries related to neurocritical care genetics.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1933-7213, 1878-7479eISSN: 1878-7479DOI: 10.1007/s13311-020-00837-2Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7283396
- Format
- –
- Schlagworte
- Animals, Biomedical and Life Sciences, Biomedicine, Critical Care - methods, Critical Care - trends, Critical Illness - therapy, FDA approval, Genetic diversity, Genetic Variation, Genetics, Population - methods, Genetics, Population - trends, Humans, Nervous System Diseases - genetics, Nervous System Diseases - therapy, Neurobiology, Neurology, Neurology - methods, Neurology - trends, Neurosciences, Neurosurgery, Population genetics, Rehabilitation, Review, Therapeutic applications