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Autor(en) / Beteiligte

Titel

First experience of SARS‐CoV‐2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study

Ist Teil von

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, comprehensive data of SARS‐CoV‐2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS‐CoV‐2 infection among SOT recipients. Overall, 21 patients were included with a median age of 56 years (10 kidney, 5 liver, 1 pancreas, 1 lung, 1 heart and 3 combined transplantations). The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%), and diarrhea (33%). Ninety‐five percent and 24% of patients required hospital and ICU admission, respectively, and 19% were intubated. After a median of 33 days of follow‐up, 16 patients were discharged, 3 were still hospitalized and 2 patients died. These data suggest that clinical manifestations of SARS‐CoV‐2 infection in middle‐aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. These results need to be confirmed in larger cohorts. This study describes the epidemiology, clinical presentation, treatment, and outcome of the first 21 solid organ transplant recipients infected with SARS‐CoV‐2 in the Swiss Transplant Cohort Study.

Sprache: Englisch
Identifikatoren: ISSN: 1600-6135
eISSN: 1600-6143
DOI: 10.1111/ajt.16062
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7272999

Format: –
Schlagworte: Aged, Betacoronavirus, Brief Communication, Brief Communications, clinical research/ practice, Cohort analysis, Comorbidity, complication: infectious, Coronavirus Infections - epidemiology, Coronaviruses, Cough, COVID-19, Diarrhea, Disease Transmission, Infectious - prevention & control, Epidemiology, Female, Fever, Follow-Up Studies, Heart transplantation, Humans, Immunocompromised hosts, Incidence, infection and infectious agents, infection and infectious agents ‐ viral, Infections, infectious disease, Male, Middle Aged, Nausea, Organ Transplantation - methods, Pancreas transplantation, Pandemics, Patients, Pneumonia, Viral - epidemiology, Postoperative Complications - epidemiology, Prospective Studies, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, Survival Rate - trends, Switzerland - epidemiology, Transplant Recipients

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