Details

Autor(en) / Beteiligte

• Youn, Je-In
• Park, Su-Myeong
• Park, Seyeon
• Kim, Gamin
• Lee, Hee-Jae
• Son, Jimin
• Hong, Min Hee
• Ghaderpour, Aziz
• Baik, Bumseo
• Islam, Jahirul
• Choi, Ji-Woong
• Lee, Eun-Young
• Kim, Hang-Rae
• Seo, Sang-Uk
• Paik, Soonmyung
• Yoon, Hong In
• Jung, Inkyung
• Xin, Chun-Feng
• Jin, Hyun-Tak
• Cho, Byoung Chul
• Seong, Seung-Yong
• Ha, Sang-Jun
• Kim, Hye Ryun

Titel

Peripheral natural killer cells and myeloid-derived suppressor cells correlate with anti-PD-1 responses in non-small cell lung cancer

Ist Teil von

• Scientific reports, 2020-06, Vol.10 (1), p.9050-9050, Article 9050

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression is used to predict anti-PD-1 therapy responses in NSCLC, its accuracy is relatively less. Therefore, we sought to identify a more accurate predictive blood biomarker for evaluating anti-PD-1 response. We evaluated the frequencies of T cells, B cells, natural killer (NK) cells, polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), mononuclear myeloid-derived suppressor cells (M-MDSCs), and Lox-1 + PMN-MDSCs in peripheral blood samples of 62 NSCLC patients before and after nivolumab treatment. Correlation of immune-cell population frequencies with treatment response, progression-free survival, and overall survival was also determined. After the first treatment, the median NK cell percentage was significantly higher in responders than in non-responders, while the median Lox-1+ PMN-MDSC percentage showed the opposite trend. NK cell frequencies significantly increased in responders but not in non-responders. NK cell frequency inversely correlated with that of Lox-1 + PMN-MDSCs after the first treatment cycle. The NK cell-to-Lox-1 + PMN-MDSC ratio (NMR) was significantly higher in responders than in non-responders. Patients with NMRs ≥ 5.75 after the first cycle had significantly higher objective response rates and longer progression-free and overall survival than those with NMRs <5.75. NMR shows promise as an early predictor of response to further anti-PD-1 therapy.