British journal of pharmacology, 2020-07, Vol.177 (14), p.3147-3161
2020
Details
- Autor(en) / Beteiligte
- Titel
- Potential therapeutic targets and promising drugs for combating SARS‐CoV‐2
- Ist Teil von
- British journal of pharmacology, 2020-07, Vol.177 (14), p.3147-3161
- Ort / Verlag
- England: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- As of April 9, 2020, a novel coronavirus (SARS‐CoV‐2) had caused 89,931 deaths and 1,503,900 confirmed cases worldwide, which indicates an increasingly severe and uncontrollable situation. Initially, little was known about the virus. As research continues, we now know the genome structure, epidemiological and clinical characteristics, and pathogenic mechanisms of SARS‐CoV‐2. Based on this knowledge, potential targets involved in the processes of virus pathogenesis need to be identified, and the discovery or development of drugs based on these potential targets is the most pressing need. Here, we have summarized the potential therapeutic targets involved in virus pathogenesis and discuss the advances, possibilities, and significance of drugs based on these targets for treating SARS‐CoV‐2. This review will facilitate the identification of potential targets and provide clues for drug development that can be translated into clinical applications for combating SARS‐CoV‐2.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-1188eISSN: 1476-5381DOI: 10.1111/bph.15092Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7267399
- Format
- –
- Schlagworte
- Adenosine Monophosphate - analogs & derivatives, Adenosine Monophosphate - therapeutic use, Alanine - analogs & derivatives, Alanine - therapeutic use, Angiotensin II Type 1 Receptor Blockers - therapeutic use, Angiotensin-Converting Enzyme 2, Angiotensin-Converting Enzyme Inhibitors - therapeutic use, Antiviral Agents - therapeutic use, Basigin - metabolism, Benzamidines, Betacoronavirus - genetics, Betacoronavirus - metabolism, Betacoronavirus - pathogenicity, Coronavirus Infections - complications, Coronavirus Infections - drug therapy, Coronavirus Infections - immunology, Coronavirus Infections - metabolism, Coronavirus Infections - prevention & control, Coronavirus Infections - therapy, Coronaviruses, COVID-19, COVID-19 Drug Treatment, COVID-19 Serotherapy, COVID-19 Vaccines, Cytokine Release Syndrome - drug therapy, Cytokine Release Syndrome - etiology, Cytokine Release Syndrome - immunology, Drug development, Drug discovery, Epidemiology, Esters, Gabexate - analogs & derivatives, Gabexate - therapeutic use, Genome, Viral, Genomes, Guanidines - therapeutic use, Humans, Immunization, Passive, Immunosuppressive Agents - therapeutic use, Medicine, Chinese Traditional, Nucleic Acid Synthesis Inhibitors - therapeutic use, Pandemics, Pathogenesis, Peptidyl-Dipeptidase A - metabolism, Pneumonia, Viral - complications, Pneumonia, Viral - drug therapy, Pneumonia, Viral - immunology, Pneumonia, Viral - metabolism, Protease Inhibitors - therapeutic use, Review, RNA-Dependent RNA Polymerase - metabolism, SARS-CoV-2, Serine Endopeptidases - metabolism, Severe acute respiratory syndrome coronavirus 2, Spike Glycoprotein, Coronavirus - metabolism, Therapeutic applications, Viral Vaccines, Virus Internalization, Virus Replication