Details

Autor(en) / Beteiligte

• Narayan, Vivek
• Thompson, Elizabeth W.
• Demissei, Biniyam
• Ho, Jennifer E.
• Januzzi, James L.
• Ky, Bonnie

Titel

Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease

Ist Teil von

• Journal of the American College of Cardiology, 2020-06, Vol.75 (21), p.2726-2737

Erscheinungsjahr

2020

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Cardiovascular disease (CVD) and cancer are leading causes of morbidity and mortality worldwide. While conventionally managed as separate disease processes, recent research has lent insight into compelling commonalities between CVD and cancer, including shared mechanisms for disease development and progression. In this review, we discuss several pathophysiologic processes common to both CVD and cancer, such as inflammation, resistance to cell death, cellular proliferation, neurohormonal stress, angiogenesis, and genomic instability, in an effort to understand common mechanisms of both disease states. In particular, we highlight key circulating and genomic biomarkers associated with each of these processes, as well as their associations with risk and prognosis in both cancer and CVD. The purpose of this state-of-the-art review is to further our understanding of the potential mechanisms underlying cancer and CVD by contextualizing biomarkers common to both diseases. Although conventionally viewed as distinct disease processes, cardiovascular disease (CVD) and cancer share common pathophysiologic mechanisms for disease development and progression. Importantly, blood- and tissue-based biomarkers may provide insight into the mechanistic overlap underlying these two diseases. Cellular stress, inflammation, cellular proliferation, neurohormonal stress, angiogenesis, and genomic instability each represent shared mechanisms for which candidate biomarkers may improve our understanding of the fundamental commonalities, risk, and prognosis of CVD and cancer.