Details

Autor(en) / Beteiligte

• Liang, Haiyan
• Chen, Lei
• Zhao, Xian
• Zhang, Xiaolin
• Karaman, Rafik

Titel

Prediction of Drug Side Effects with a Refined Negative Sample Selection Strategy

Ist Teil von

• Computational and mathematical methods in medicine, 2020-05, Vol.2020, p.1573543-16

Ort / Verlag

United States: Hindawi

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Drugs are an important way to treat various diseases. However, they inevitably produce side effects, bringing great risks to human bodies and pharmaceutical companies. How to predict the side effects of drugs has become one of the essential problems in drug research. Designing efficient computational methods is an alternative way. Some studies paired the drug and side effect as a sample, thereby modeling the problem as a binary classification problem. However, the selection of negative samples is a key problem in this case. In this study, a novel negative sample selection strategy was designed for accessing high-quality negative samples. Such strategy applied the random walk with restart (RWR) algorithm on a chemical-chemical interaction network to select pairs of drugs and side effects, such that drugs were less likely to have corresponding side effects, as negative samples. Through several tests with a fixed feature extraction scheme and different machine-learning algorithms, models with selected negative samples produced high performance. The best model even yielded nearly perfect performance. These models had much higher performance than those without such strategy or with another selection strategy. Furthermore, it is not necessary to consider the balance of positive and negative samples under such a strategy.