Scientific reports, 2020-05, Vol.10 (1), p.7947, Article 7947
2020
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Details
- Autor(en) / Beteiligte
- Titel
- rTgOWP1-f, a specific biomarker for Toxoplasma gondii oocysts
- Ist Teil von
- Scientific reports, 2020-05, Vol.10 (1), p.7947, Article 7947
- Ort / Verlag
- London: Nature Publishing Group UK
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Toxoplasma gondii oocyst wall protein 1 (TgOWP1) integrates a family of seven proteins, consensually assumed as specific antigens of Toxoplasma gondii oocyst stage, located in the outer layer of the oocyst wall. Herein, we notice the expression of a recombinant antigen, rTgOWP1-f, derived from a fragment selected on basis of its structural homology with Plasmodium MSP1–19. Rabbit polyclonal antibodies anti-rTgOWP1-f evidence ability for specific identification of environmental T. gondii oocysts. We assume, rTgOWP1-f, as a possible biomarker of oocysts. In addition, we present findings supporting this vision, including the development of an immunodetection method for T. gondii oocysts identification.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2045-2322eISSN: 2045-2322DOI: 10.1038/s41598-020-64590-4Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7224171
- Format
- –
- Schlagworte
- 631/337, 631/45, Amino Acid Sequence, Antigens, Biomarkers, Biomarkers - metabolism, Homology, Humanities and Social Sciences, Models, Molecular, multidisciplinary, Oocyst wall protein, Oocysts, Oocysts - metabolism, Polyclonal antibodies, Protein Conformation, Protozoa, Protozoan Proteins - chemistry, Protozoan Proteins - metabolism, Science, Science (multidisciplinary), Toxoplasma - metabolism, Toxoplasma gondii