Details

Autor(en) / Beteiligte

• van de Veen, Willem
• Globinska, Anna
• Jansen, Kirstin
• Straumann, Alex
• Kubo, Terufumi
• Verschoor, Daniëlle
• Wirz, Oliver F
• Castro-Giner, Francesc
• Tan, Ge
• Rückert, Beate
• Ochsner, Urs
• Herrmann, Marietta
• Stanić, Barbara
• van Splunter, Marloes
• Huntjens, Daan
• Wallimann, Alexandra
• Fonseca Guevara, Rodney J
• Spits, Hergen
• Ignatova, Desislava
• Chang, Yun-Tsan
• Fassnacht, Christina
• Guenova, Emmanuella
• Flatz, Lukas
• Akdis, Cezmi A
• Akdis, Mübeccel

Titel

A novel proangiogenic B cell subset is increased in cancer and chronic inflammation

Ist Teil von

• Science advances, 2020-05, Vol.6 (20), p.eaaz3559-eaaz3559

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• B cells contribute to immune responses through the production of immunoglobulins, antigen presentation, and cytokine production. Several B cell subsets with distinct functions and polarized cytokine profiles have been reported. In this study, we used transcriptomics analysis of immortalized B cell clones to identify an IgG4 B cell subset with a unique function. These B cells are characterized by simultaneous expression of proangiogenic cytokines including VEGF, CYR61, ADM, FGF2, PDGFA, and MDK. Consequently, supernatants from these clones efficiently promote endothelial cell tube formation. We identified CD49b and CD73 as surface markers identifying proangiogenic B cells. Circulating CD49b CD73 B cells showed significantly increased frequency in patients with melanoma and eosinophilic esophagitis (EoE), two diseases associated with angiogenesis. In addition, tissue-infiltrating IgG4 CD49b CD73 B cells expressing proangiogenic cytokines were detected in patients with EoE and melanoma. Our results demonstrate a previously unidentified proangiogenic B cell subset characterized by expression of CD49b, CD73, and proangiogenic cytokines.