Details

Autor(en) / Beteiligte

• Ma, Cuiqing
• Su, Shan
• Wang, Jiachao
• Wei, Lin
• Du, Lanying
• Jiang, Shibo

Titel

From SARS-CoV to SARS-CoV-2: safety and broad-spectrum are important for coronavirus vaccine development

Ist Teil von

• Microbes and infection, 2020-07, Vol.22 (6-7), p.245-253

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The global pandemic of COVID-19 caused by SARS-CoV-2 (also known as 2019-nCoV and HCoV-19) has posed serious threats to public health and economic stability worldwide, thus calling for development of vaccines against SARS-CoV-2 and other emerging and reemerging coronaviruses. Since SARS-CoV-2 and SARS-CoV have high similarity of their genomic sequences and share the same cellular receptor (ACE2), it is essential to learn the lessons and experiences from the development of SARS-CoV vaccines for the development of SARS-CoV-2 vaccines. In this review, we summarized the current knowledge on the advantages and disadvantages of the SARS-CoV vaccine candidates and prospected the strategies for the development of safe, effective and broad-spectrum coronavirus vaccines for prevention of infection by currently circulating SARS-CoV-2 and other emerging and reemerging coronaviruses that may cause future epidemics or pandemics.