Details

Autor(en) / Beteiligte

• Cabrera-Lobera, Natalia
• Quirós, M. Teresa
• Brennessel, William W
• Neidig, Michael L
• Buñuel, Elena
• Cárdenas, Diego J

Titel

Atom-Economical Ni-Catalyzed Diborylative Cyclization of Enynes: Preparation of Unsymmetrical Diboronates

Ist Teil von

• Organic letters, 2019-08, Vol.21 (16), p.6552-6556

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We report a Ni-catalyzed diborylative cyclization of enynes that affords carbo- and heterocycles containing both alkyl- and alkenylboronates. The reaction is fully atom-economical, shows a broad scope, and employs a powerful and inexpensive catalytic Ni-based system. The reaction mechanism seems to involve activation of the enyne by Ni(0) through oxidative cyclometalation of the enyne prior to diboron reagent activation. An unprecedented dinuclear bis­(organometallic) Ni­(I) intermediate complex was isolated.