Details

Autor(en) / Beteiligte

• Galeotti, Caroline
• Kaveri, Srini V.
• Cimaz, Rolando
• Koné-Paut, Isabelle
• Bayry, Jagadeesh

Titel

Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki disease

Ist Teil von

• Drug discovery today, 2016-11, Vol.21 (11), p.1850-1857

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• •Kawasaki disease (KD) is an acute childhood disease with coronary artery lesions.•Endothelial cell injury is mediated by T cells and cytokines (TNF-α and IL-1β).•KD is due to an abnormal immunological response in genetically predisposed individuals.•Candidate KD susceptibility genes identified by GWAS include BLK, CD40 and FCGR2A.•Intravenous immunoglobulin and aspirin are the standard treatment of acute KD.•IVIG-resistant patients are treated with steroids, cyclosporine, anti-IL-1β or anti-TNF. Kawasaki disease (KD) is an acute febrile childhood inflammatory disease, associated with coronary artery abnormalities. The disease is believed to result from an aberrant inflammatory response to an infectious trigger in a genetically predisposed individual. KD is associated with an endothelial cell injury as a consequence of T cell activation and cytotoxic effects of various proinflammatory cytokines. Intravenous immunoglobulin (IVIG) infusion and aspirin are the standard treatment of acute KD. However, 10–20% of patients show resistance to IVIG therapy and present higher risk of coronary vasculitis. The relative roles of second IVIG infusion, corticosteroids, calcineurin inhibitors, interleukin-1 antagonists and anti-tumor necrosis factor agents remain uncertain. In this review, we highlight the predisposing factors, pathogenesis and therapeutic intervention of KD, particularly new therapeutics for IVIG-resistant patients.