Details

Autor(en) / Beteiligte

• Avilla, Mele N
• Malecki, Kristen M. C
• Hahn, Mark E
• Wilson, Rachel H
• Bradfield, Christopher A

Titel

The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model

Ist Teil von

• Chemical research in toxicology, 2020-04, Vol.33 (4), p.860-879

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The Ah receptor (AHR) has been studied for almost five decades. Yet, we still have many important questions about its role in normal physiology and development. Moreover, we still do not fully understand how this protein mediates the adverse effects of a variety of environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), the chlorinated dibenzo-p-dioxins (“dioxins”), and many polyhalogenated biphenyls. To provide a platform for future research, we provide the historical underpinnings of our current state of knowledge about AHR signal transduction, identify a few areas of needed research, and then develop concepts such as adaptive metabolism, ligand structural diversity, and the importance of proligands in receptor activation. We finish with a discussion of the cognate physiological role of the AHR, our perspective on why this receptor is so highly conserved, and how we might think about its cognate ligands in the future.