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A cell‐based high‐throughput protocol to screen entry inhibitors of highly pathogenic viruses with Traditional Chinese Medicines
Journal of medical virology, 2017-05, Vol.89 (5), p.908-916
Yang, Yong
Cheng, Han
Yan, Hui
Wang, Peng‐Zhan
Rong, Rong
Zhang, Ying‐Ying
Zhang, Cheng‐Bo
Du, Rui‐kun
Rong, Li‐Jun
2017
Details
Autor(en) / Beteiligte
Yang, Yong
Cheng, Han
Yan, Hui
Wang, Peng‐Zhan
Rong, Rong
Zhang, Ying‐Ying
Zhang, Cheng‐Bo
Du, Rui‐kun
Rong, Li‐Jun
Titel
A cell‐based high‐throughput protocol to screen entry inhibitors of highly pathogenic viruses with Traditional Chinese Medicines
Ist Teil von
Journal of medical virology, 2017-05, Vol.89 (5), p.908-916
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Emerging viruses such as Ebola virus (EBOV), Lassa virus (LASV), and avian influenza virus H5N1 (AIV) are global health concerns. Since there is very limited options (either vaccine or specific therapy) approved for humans against these viruses, there is an urgent need to develop prophylactic and therapeutic treatments. Previously we reported a high‐throughput screening (HTS) protocol to identify entry inhibitors for three highly pathogenic viruses (EBOV, LASV, and AIV) using a human immunodeficiency virus–based pseudotyping platform which allows us to perform the screening in a BSL‐2 facility. In this report, we have adopted this screening protocol to evaluate traditional Chinese Medicines (TCMs) in an effort to discover entry inhibitors against these viruses. Here we show that extracts of the following Chinese medicinal herbs exhibit potent anti‐Ebola viral activities: Gardenia jasminoides Ellis, Citrus aurantium L., Viola yedoensis Makino, Prunella vulgaris L., Coix lacryma‐jobi L. var. mayuen (Roman.) Stapf, Pinellia ternata (Thunb.) Breit., and Morus alba L. This study represents a proof‐of‐principle investigation supporting the suitability of this assay for rapid screening TCMs and identifying putative entry inhibitors for these viruses. J. Med. Virol. 89:908–916, 2017. © 2016 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.24705
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7167059
Format
–
Schlagworte
Antiviral Agents - isolation & purification
,
Antiviral Agents - pharmacology
,
antiviral drugs
,
Bioassays
,
Chinese medicine
,
Citrus aurantium
,
Coix lacryma-jobi
,
Drug Evaluation, Preclinical - methods
,
Ebola virus
,
Ebolavirus
,
Ebolavirus - drug effects
,
Ebolavirus - physiology
,
entry inhibitors
,
Gardenia jasminoides
,
High-Throughput Screening Assays
,
high‐throughput screening
,
Humans
,
Lassa virus
,
Medical screening
,
Morus alba
,
Orthomyxoviridae
,
Pathogens
,
Pinellia ternata
,
Plant Extracts - isolation & purification
,
Plant Extracts - pharmacology
,
Plants, Medicinal - chemistry
,
Prunella vulgaris
,
Traditional Chinese Medicine
,
Virology
,
Virus Internalization - drug effects
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