Clinical cancer research, 2020-04, Vol.26 (8), p.1784-1786
2020
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Double Trouble: Concomitant RB1 and BRCA2 Depletion Evokes Aggressive Phenotypes
- Ist Teil von
- Clinical cancer research, 2020-04, Vol.26 (8), p.1784-1786
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Coordinate single- or two copy loss of the / tumor suppressor genes, which reside in close chromosomal proximity, were found to be associated with aggressive prostate cancer and therapeutic resistance. Modeling these events and analyses of human cancers suggest that dual depletion of may represent a distinct subtype of disease. .
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-0432eISSN: 1557-3265DOI: 10.1158/1078-0432.ccr-19-4033Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7165038
- Format
- –
- Schlagworte
- BRCA2 Protein, Disease Progression, Genes, BRCA2, Humans, Male, Phenotype, Prostatic Neoplasms - genetics